New York, USA - November 26, 2025 - Alfa Cytology today releases the development of its proprietary Alfa-TIL™ platform, a comprehensive, integrated system designed to overcome the key challenges in Tumor-Infiltrating Lymphocyte (TIL) therapy manufacturing and accelerate the development of next-generation TIL-based immunotherapies.
TIL therapy is a promising new area in cancer treatment that utilizes the patient's own immune cells to combat solid tumors. However, the implementation of this promising technology has been limited by the time-consuming, complex, and inconsistent manufacturing processes. The Alfa-TIL™ technology platform helps to solve these problems through a number of additional refining technologies designed to maximize the expansion, potency, and consistency of the TIL products.
Alfa Cytology is focused on turning the great promise of cell therapy into clinical cures for cancer patients, but the bottleneck of conventional TIL manufacturing has been a significant barrier. The tumor-infiltrating lymphocyte research platform is a game-changer. It is engineered to reliably produce high-quality, potent TILs more rapidly and efficiently, which makes it a clinically promising, tumor-specific approach with growing relevance in preclinical innovation and therapeutic discovery.
Workflow of Alfa-TIL™ Platform
• Low-Input and Rapid TIL Isolation and Expansion: reliable and time-efficient TIL isolation and expansion using small amounts of tumor tissue, specifically suitable for preclinical studies where sample availability is limited or time is a critical factor.
• TIL Genetic Engineering for Functional Enhancement: enable targeted gene modifications to enhance TIL function, durability, or resistance to immunosuppressive signals, making the next-generation TIL designs in a controlled preclinical setting.
• Multi-Omics TIL Profiling: support transcriptomic and immune phenotyping analysis of TILs to reveal functional signatures, clonality, and exhaustion states.
• Preclinical TIL Functional Validation: in vitro and in vivo assays to evaluate TIL antitumor activity, including cytotoxicity, cytokine release, and efficacy in animal models.
The low-input isolation, genetic engineering, and functional validation enable the Alfa-TIL™ platform to provide a rapid assessment of tumor-specific TIL performance across multiple disease contexts. By providing a more robust and predictable manufacturing foundation, the Alfa-TIL™ platform allows researchers to focus on therapeutic innovation rather than process variability. This is a critical step towards realizing the full potential of TIL immunotherapy for solid tumors, such as breast cancer, liver cancer, lung cancer, and cervical cancer.
About Alfa Cytology
Alfa Cytology is a biotech company dedicated to accelerating the development of innovative cancer immunotherapies. By leveraging its proprietary research and platform technologies, the company aims to provide comprehensive preclinical solutions that bridge the gap between foundational research and clinical application, ultimately contributing to the advancement of next-generation treatments for patients.
Media Contact
Company Name: Alfa Cytology
Contact Person: Toya Davis
Email: Send Email
Country: United States
Website: https://www.alfacytology.com/til