Articles from Global Coalition for Adaptive Research

The Global Coalition for Adaptive Research (GCAR) in collaboration with Cure Brain Cancer Foundation (CBCF), today announced the opening of GBM AGILE (Glioblastoma Adaptive Global Innovative Learning Environment – NCT03970447) in Australia. GBM AGILE is a revolutionary patient-centered, adaptive platform trial for registration that evaluates multiple therapies for patients with newly-diagnosed and recurrent glioblastoma (GBM) – the deadliest form of brain cancer.

Global Coalition for Adaptive Research (GCAR) is proud to announce its partnership with the South Pole Trek 4 Cancer. In December, Lance Kawaguchi, a former banker who is now the CEO of a non-profit, will embark on a remarkable journey to Antarctica and the South Pole. His mission: to raise a flag in honor of cancer, representing not only GCAR, but also 22 other esteemed cancer charities worldwide.

The Global Coalition for Adaptive Research (GCAR) in collaboration with the University of Pittsburgh and UPMC, on behalf of the REMAP-CAP Investigator Network, announce clinical trial results examining the use of vitamin C and simvastatin to treat severely ill patients with COVID-19.

Global Coalition for Adaptive Research (LARKSPUR, CA) and Polaris Pharmaceuticals, Inc. (SAN DIEGO, CA), a subsidiary of Polaris Group (TWSE:6550)— The Global Coalition for Adaptive Research (GCAR) in collaboration with Polaris, today announced the activation of ADI-PEG 20 in GBM AGILE (Glioblastoma Adaptive Global Innovative Learning Environment – NCT03970447). GBM AGILE is a revolutionary patient-centered, adaptive platform trial for registration that evaluates multiple therapies for patients with newly-diagnosed and recurrent glioblastoma (GBM) – the deadliest form of brain cancer.

Global Coalition for Adaptive Research (GCAR), a 501(c)(3) non-profit research organization, announced that together with their patient/advocacy and pharma/biotech partners, they will ring the Nasdaq Stock Market Closing Bell today to spotlight National Brain Tumor Awareness Month and their innovative, global brain tumor trial called GBM AGILE.

Global Coalition for Adaptive Research (GCAR), Sponsor of GBM AGILE (Glioblastoma Adaptive Global Innovative Learning Environment) master protocol, announced that regorafenib has completed enrollment and follow-up in GBM AGILE. Enrollment for the arm was stopped after an interim analysis showed a low probability of sufficient improvement in overall survival as compared with randomized controls.

Global Coalition for Adaptive Research (LARKSPUR, CA), Biohaven Pharmaceutical Holding Company Ltd. (NYSEBHVN), and Vigeo Therapeutics -- The Global Coalition for Adaptive Research (GCAR) in collaboration with Biohaven and Vigeo Therapeutics, today announced the activation of Biohaven's troriluzole and Vigeo's VT1021 in GBM AGILE (Glioblastoma Adaptive Global Innovative Learning Environment). GBM AGILE is a revolutionary patient-centered, adaptive platform trial for registration that tests multiple therapies for patients with newly-diagnosed and recurrent glioblastoma (GBM) – the deadliest form of brain cancer.

Global Coalition for Adaptive Research, the U.S. Sponsor of REMAP-COVID, announced that Eisai has ended the evaluation of eritoran in the REMAP-COVID study. Eritoran, an investigational TLR-4 antagonist discovered and developed by Eisai, was selected for evaluation because it was hypothesized to suppress the over-production and release of various pro-inflammatory mediators (“cytokine storm”) observed in some COVID-19 patients by modulating the production of inflammatory cytokines. The decision to terminate the evaluation was due to changes in the COVID-19 landscape.

Global Coalition for Adaptive Research (GCAR) today announced an update on the progress of GBM AGILE (Glioblastoma Adaptive Global Innovative Learning Environment - NCT03970447). GBM AGILE is a revolutionary patient-centered, adaptive platform trial for registration that tests multiple therapies for patients with newly-diagnosed and recurrent glioblastoma (GBM) – the deadliest form of brain cancer.

Global Coalition for Adaptive Research (GCAR) announces a new clinical trial initiative, Ovarian CanceRx™. This innovative trial, referred to as an adaptive platform trial, is designed to test multiple drugs simultaneously against the standard of care treatments to rapidly test and deliver new therapies to patients with advanced ovarian cancer or recurrent platinum-resistant disease.

Global Coalition for Adaptive Research, the U.S. Sponsor of REMAP-COVID, announced that Amgen’s apremilast (Otezla) has ended evaluation in the REMAP-COVID study. Apremilast, an oral drug which inhibits the activity of PDE4 (Phosphodiesterase 4), was selected for evaluation because it was hypothesized to inhibit the inflammatory response associated with the signs, symptoms and pulmonary involvements observed in some COVID-19 patients by modulating the production of inflammatory cytokines.